UCC develops arsenal of alternatives to antibiotics

Photo: L-R Orla O'Sullivan, Paula O'Connor, Fergus Collins and Mary Read
L-R Orla O’Sullivan, Paula O’Connor, Fergus Collins and Mary Read

Scientists at the APC Microbiome Institute at UCC have identified an arsenal of new antimicrobials which can kill many harmful bacteria.

The latest antimicrobial, called formicin, is a bacteriocin which is a small bacterially produced antimicrobial protein. The research on formicin has been picked up by the editor of the journal Microbiology where it is highlighted and published this week.

“Formicin was picked up in our most recent screening for new antimicrobials. We have identified 20 new small proteins to date including Thuricin and Lacticin 3147” said Professor Paul Ross, who leads the research with Professor Colin Hill at the APC Microbiome Institute in University College Cork and Teagasc. “We plan to further develop these compounds which have important implications for human and animal health.”

Antimicrobial resistance poses one of the biggest threats to global health today.  According to the WHO (2015) antibiotic resistance in the European Union alone, is estimated to cause 25,000 deaths and cost more than US$1.5 billion every year in healthcare expenses and productivity losses. Without effective antibiotics for the prevention and treatment of infections, many of the achievements of modern medicine such as organ transplantations, chemotherapy and surgeries such as caesarean sections become much more dangerous.

“The new antimicrobial, Formicin, was isolated from Bacillus paralichenformis APC1576, a bacteria which was originally isolated from the intestine of a mackerel” said Fergus Collins, the PhD student at Teagasc, Moorepark who discovered Formicin. “Formicin can kill a wide range of harmful bacteria including the Gram positive pathogensStaphyloccous aureus, Clostridium difficile, Listeria monocytogenes and Steptococcus mutans, a causative agent of tooth decay.”

Formicin is a member of a subclass of bacteriocins called lantibiotics which contain certain modified amino acids.  Formicin  is made up of 2 lantibiotic peptides.  The first peptide likely binds to the cell membrane of the bacterial target and subsequently recruits the second formicin peptide which then inserts into the membrane; the resulting pore formed then causes cell death. Formicin is unique among lantibiotics due to differences in the peptide’s charge and composition.

This research was supported by Science Foundation Ireland through a Research Centre grant to the APC Microbiome Institute.

 

Full reference:

Formicin – A novel broad spectrum two-component lantibiotic produced by Bacillus paralicheniformis APC 1576

Collins F.W., O’Connor, P.M., O’Sulllivan, O., Rea, M.C., Hill, C. and Ross R.P.  Microbiology, September 2016 162: 1662-1671, doi: 10.1099/mic.0.000340

http://mic.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.000340#tab2

 

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27450592

For further information contact Dr Catherine Buckley, Communications & O